Research
CoMet Lab
Laboratory for Computational and Mathematical modeling in Medicine Engineering and Technology
CoMET Lab is an interdisciplinary research group that promotes mathematical and computational methods as virtual laboratories to address problems in medicine, engineering and technology.
Illustrator: M.T. Aulisa
Current team
Giovanna Guidoboni, Director
Professor, Electrical Engineering and Computer Science, Mathematics
University of Missouri
Riccardo Sacco
Associate Professor, Mathematics
Politecnico di Milano, Italy
Roberto Nunez
Post-doctoral fellow, Electrical Engineering and Computer Science, University of Missouri
Mohamed Zaid
PhD Student, Electrical and Computer Engineering, University of Missouri
Rajat Rai
PhD Student, Electrical and Computer Engineering, University of Missouri
Daphne Zou
PhD Student, Computer Science
University of Missouri
Brent Koogler
PhD Student, Mathematics
University of Missouri
Kenya Massey
PhD Student, Sociology
University of Missouri
Lily Ikoh
MS Student, Applied Mathematics
University of Missouri
Aaron Beckwith
MS Student, Applied Mathematics
University of Missouri
Ryan Sellers
Undergraduate Student, Computer Science
University of Missouri
Maggie Lin
High School Student, Rock Bridge High School
Columbia, MO
Max Litton
High School Student, Rock Bridge High School
Columbia, MO
Major Ongoing Projects
The eye and the body
The eye is the only place in the human body where blood vessels are accessible to noninvasive measurements down to the capillary level. Our research aims at disentangling systemic and local factors that contribute to ocular hemodynamics in order to enable nonivasive measurements in the eye as a window on the status of the eye, the brain and the whole body.
Mathematical and numerical aspects of multiscale and multiphysics models
Problems arising in engineering, medicine and the applied sciences are naturally multiscale and multiphysics. Our research aims at developing mathematical and computational techniques that are necessary to address the complexity of life.
Combining Mechanism-Driven and Data-Driven models to unlock organ function
What is we could build a whole organ simulator by using mechanistic models for what we know and letting a machine learn what we do not know? Our group has joined forces with scientists from 4 other US institutions to make this vision come true for the lower urinary tract.
Noninvasive cardiovascular monitoring
While it is very clear that the "one size fits all" approach is not effective in many areas of medicine, there are so many factors that vary from person to person that it remains very challenging to pin down those that are most relevant in each one of us. Our group is addressing this question by combining mathematical and computational methods with clinical and experimental studies.
Understanding the impact of COVID-19 in rural and urban areas in Missouri
How are rural and urban areas affected by the current pandemic? How can we better address the diverse needs of the people in the state of Missouri and assist them during this time? Our group has joined forces with an interdisciplinary group of scientists to address these issues.
Microvascular exchange and lymphatic function
Why are cardiovascular diseases affecting men and women in different ways? How is the fluid and protein balance achieved within the tissue, and is it different in males and females? What is the role of the lymphatic system in achieving this balance? Our group is addressing these challenging questions by combining experiments and simulations.
National and International Collaborations
Our activities are conducted in collaboration with many institutions, offering numerous opportunities for both faculty and students.
Major partner institutions include:
- Florida International University (FL)
- Icahn School of Medicine at Mount Sinai (NY)
- North Carolina State University (NC)
- Northeastern University (MA)
- Politecnico di MIlano (Italy)
- University of Strasbourg (France)
- University of Paris-Descartes (France)
- University of Wisconsin-Madison (WI)
- US Military Academy (West Point, NY)
- Washington State University (WA)
PhD Graduates
[06/2020] Farah Abdelhafid
Mathematics, University of Missouri
Thesis: Mathematical and computational modeling of fluid flow with applications in ophthalmology and geoscience
[09/2019] Lorenzo Sala
Mathematics, University of Strasbourg (France)
Thesis: Modélisation mathématique et simulation de flux sanguins oculaires et leur interactions
[11/2016] Daniele Prada
Mathematics, Indiana University Purdue University Indianapolis
[05/2016] Lucia Carichino
Mathematics,, Indiana University Purdue University Indianapolis
Thesis: Multiscale modeling of ocular blood flow and oxygenation and their relevance to glaucoma
[05/2016] Simone Cassani
Mathematics, Indiana University Purdue University Indianapolis
Thesis: Blood circulation and aqueous humor flow in the eye: multi-scale modeling and clinical applications
MS Graduates - Thesis
[07/2021] Paolo Ranieri
Civil Engineering, Politecnico di Milano, Politecnico di Torino, Italy
[12/2020] Nicholas Mattia Marazzi
Electrical and Computer Engineering, University of Missouri
Thesis: Ballistocardiography: physically-based modeling to bridge physiology and technology
[04/2019] Francesca Bellucci
Mathematical Engineering, Politecnico di Milano, Italy
Thesis: Reduced modeling of ballistocardiograms for passive sensing of cardiovascular health
[12/2018] Giulio Bonifazi
Mathematical Engineering, Politecnico di Milano, Italy
[12/2018] Greta Chiaravalli
Engineering Physics, Politecnico di Milano, Italy
[12/2018] Nicholas Mattia Marazzi
Civil Engineering, Politecnico di Milano, Italy
Thesis: An engineering approach to the multiscale modeling of the lymphatic system
[12/2017] Francesca Stefanoni
Biomedical Engineering, Politecnico di Milano, Italy
[12/2017] Fabrizia Salerni
Bioengineering, Universitá degli Studi di Genova (Italy)
Thesis: Design and development of a mathematical model to analyse visual impairment in astronauts
[06/2016] Bassel Haydar
Mathematics, University of Strasbourg (France)
Thesis: Lumped parameter models for cerebrospinal hydrodynamics during the cardiac cycle
[04/2016] Lorenzo Sala
Mathematical Engineering, Politecnico di Milano, Italy
Thesis: A cellular scale model of aqueous humor production
[12/2015] Alessandra Cardani
Mathematical Engineering, Politecnico di Milano, Italy
Thesis: Theoretical analysis of neurovascular mechanisms contributing to retinal blood flow regulation
MS Graduates - Projects
[05/2021] Rajani Kanth Yempalla
Computer Science, University of Missouri
Project: Mechanism-driven mathematical modeling to study organ function: applications to the cardiovascular system and the lower urinary tract
[07/2020] Snighda Pasham
Computer Science, University of Missouri
Project: Comprehensive software platform for analyzing physiological data and Utilization of a closed-loop mathematical model to characterize cardiovascular implications of sex differences in biophysical parameters
[05/2020] Jessica Wellington
Applied Mathematics, University of Missouri
Project: Development of a mathematical model to investigate iron allocation in plants
[05/2020] Emily Lichtenegger
Applied Mathematics, University of Missouri
Project: Modeling the three main vascular beds in the eye and their connections